RT Journal Article SR Electronic T1 Tissue-specific cancer paradox and mutation rates JF bioRxiv FD Cold Spring Harbor Laboratory SP 012658 DO 10.1101/012658 A1 Valentina Agoni YR 2014 UL http://biorxiv.org/content/early/2014/12/15/012658.abstract AB Some genes have ubiquitous expression patterns in an individual’s cells, thus a paradox exists whereby mutations in such genes are only strongly associated with cancers of specific tissues. As these genes are ubiquitously expressed in the body’s cells and thereby have functions in -potentially- all tissue types, then surely their resulting defects would manifest as cancers in all tissues?We hypothesize that the different susceptibility to mutations could explain the ‘tissue-specific’ paradox for cancer.