PT  - JOURNAL ARTICLE
AU  - Valentina Agoni
TI  - Tissue-specific cancer paradox and mutation rates
AID  - 10.1101/012658
DP  - 2014 Jan 01
TA  - bioRxiv
PG  - 012658
4099  - http://biorxiv.org/content/early/2014/12/15/012658.short
4100  - http://biorxiv.org/content/early/2014/12/15/012658.full
AB  - Some genes have ubiquitous expression patterns in an individual’s cells, thus a paradox exists whereby mutations in such genes are only strongly associated with cancers of specific tissues. As these genes are ubiquitously expressed in the body’s cells and thereby have functions in -potentially- all tissue types, then surely their resulting defects would manifest as cancers in all tissues?We hypothesize that the different susceptibility to mutations could explain the ‘tissue-specific’ paradox for cancer.