RT Journal Article
SR Electronic
T1 Genomic architecture of human neuroanatomical diversity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 001198
DO 10.1101/001198
A1 Roberto Toro
A1 Jean-Baptiste Poline
A1 Guillaume Huguet
A1 Eva Loth
A1 Vincent Frouin
A1 Tobias Banaschewski
A1 Gareth J Barker
A1 Arun Bokde
A1 Christian Büchel
A1 Fabiana M Carvalho
A1 Patricia Conrod
A1 Mira Fauth-Bühler
A1 Herta Flor
A1 Jürgen Gallinat
A1 Hugh Garavan
A1 Penny Gowland
A1 Andreas Heinz
A1 Bernd Ittermann
A1 Claire Lawrence
A1 Hervé Lemaître
A1 Karl Mann
A1 Frauke Nees
A1 Tomáš Paus
A1 Zdenka Pausova
A1 Marcella Rietschel
A1 Trevor Robbins
A1 Michael N Smolka
A1 Andreas Ströhle
A1 Gunter Schumann
A1 Thomas Bourgeron
A1 and the IMAGEN consortium ( )
YR 2013
UL http://biorxiv.org/content/early/2013/12/05/001198.abstract
AB Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here we show, based on our analyses of neuroimaging and whole-genome genotyping data from 1,765 subjects, that up to 54% of this heritability is captured by large numbers of single nucleotide polymorphisms of small effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.