RT Journal Article
SR Electronic
T1 Can the location of a trophectoderm biopsy contribute to human blastocyst development ?
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 109298
DO 10.1101/109298
A1 Tomoe Takano, M.Sc.
A1 Miyako Funabiki, M.D.
A1 Sagiri Taguchi, M.D., Ph.D.
A1 Fumie Saji, Ph.D.
A1 Namiko Amano, B.Sc.
A1 Kate Young Louise, B.Sc.
A1 Yoshitaka Nakamura, M.D.
YR 2017
UL http://biorxiv.org/content/early/2017/02/20/109298.abstract
AB The influence of the location of a trophectoderm biopsy in human blastocysts on the development of those blastocysts has not yet been investigated. In our prospective study (n=92), our multivariate logistic regression analysis indicated that blastocoel development was influenced by the location of the trophectoderm biopsy (p=0.049) and by the type of human blastocyst used (fresh or thawed) (p=0.037), regardless of the patient’s age (p=0.507) and the number of days for the human blastocyst in the pretrophectoderm biopsy (p=0.239). Therefore, when a trophectoderm biopsy is close to the inner cell mass (ICM) in human blastocysts, it improves the progress of blastocoel development.Clinical evidence suggests that the progress of blastocoel development is a predictor of clinical outcomes after single blastocyst transfer. Therefore, when the trophectoderm biopsy is done from near the ICM, improvement of clinical outcomes after single blastocyst transfer may be expected.