RT Journal Article
SR Electronic
T1 Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 106674
DO 10.1101/106674
A1 Sydney M. Nguyen
A1 Kathleen M. Antony
A1 Dawn M. Dudley
A1 Sarah Kohn
A1 Heather A. Simmons
A1 Bryce Wolfe
A1 M. Shahriar Salamat
A1 Leandro B. C. Teixeira
A1 Gregory J. Wiepz
A1 Troy H. Thoong
A1 Matthew T. Aliota
A1 Andrea M. Weiler
A1 Gabrielle L. Barry
A1 Kim L. Weisgrau
A1 Logan J. Vosler
A1 Mariel S. Mohns
A1 Meghan E. Breitbach
A1 Laurel M. Stewart
A1 Mustafa N. Rasheed
A1 Christina M. Newman
A1 Michael E. Graham
A1 Oliver E. Wieben
A1 Patrick A. Turski
A1 Kevin M. Johnson
A1 Jennifer Post
A1 Jennifer M. Hayes
A1 Nancy Schultz-Darken
A1 Michele L. Schotzko
A1 Josh A. Eudailey
A1 Sallie R. Permar
A1 Eva G. Rakasz
A1 Emma L. Mohr
A1 Saverio Capuano III
A1 Alice F. Tarantal
A1 Jorge E. Osorio
A1 Shelby L. O’Connor
A1 Thomas C. Friedrich
A1 David H. O’Connor
A1 Thaddeus G. Golos
YR 2017
UL http://biorxiv.org/content/early/2017/02/11/106674.abstract
AB Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection.