PT - JOURNAL ARTICLE AU - Elizabeth DuPre AU - R. Nathan Spreng TI - Structural covariance networks across the lifespan, from 6-94 years of age AID - 10.1101/090233 DP - 2017 Jan 01 TA - bioRxiv PG - 090233 4099 - http://biorxiv.org/content/early/2017/02/08/090233.short 4100 - http://biorxiv.org/content/early/2017/02/08/090233.full AB - Structural covariance examines covariation of grey matter morphology between brain regions and across individuals. Despite significant interest in the influence of age on structural covariance patterns, no study to date has provided a complete lifespan perspective—bridging childhood with early, middle, and late adulthood—on the development of structural covariance networks. Here, we investigate the lifespan trajectories of structural covariance in six canonical neurocognitive networks: default, dorsal attention, frontoparietal control, somatomotor, ventral attention, and visual. By combining data from five open access data sources, we examine the structural covariance trajectories of these networks from 6-94 years of age in a sample of 1580 participants. Using partial least squares, we show that structural covariance patterns across the lifespan exhibit two significant, age-dependent trends. The first trend is a stable pattern whose integrity declines over the lifespan. The second trend is an inverted-U that differentiates young adulthood from other age groups. Hub regions, including posterior cingulate cortex and anterior insula, appear particularly influential in the expression of this second age-dependent trend. Overall, our results suggest that structural covariance provides a reliable definition of neurocognitive networks across the lifespan and reveal both shared and network-specific trajectories.Author Summary The importance of lifespan perspectives is increasingly apparent in understanding normative interactions of large-scale neurocognitive networks. Although recent work has made significant strides in understanding the functional and structural connectivity of these networks, there has been comparatively little attention to lifespan trajectories of structural covariance networks. In this study we examine patterns of structural covariance across the lifespan for six neurocognitive networks. Our results suggest that networks exhibit both network-specific stable patterns of structural covariance as well as shared age-dependent trends. Previously identified hub regions seem to show a strong influence on the expression of these age-related trajectories. These results provide initial evidence for a multi-modal understanding of structural covariance in network structure-function interaction across the life course.