TY - JOUR T1 - A probabilistic approach to discovering dynamic full-brain functional connectivity patterns JF - bioRxiv DO - 10.1101/106690 SP - 106690 AU - Jeremy R. Manning AU - Xia Zhu AU - Theodore L. Willke AU - Rajesh Ranganath AU - Kimberly Stachenfeld AU - Uri Hasson AU - David M. Blei AU - Kenneth A. Norman Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/02/07/106690.abstract N2 - Recent work indicates that the covariance structure of functional magnetic resonance imaging (fMRI) data – commonly described as functional connectivity – can change as a function of the participant’s cognitive state (for review see [32]). Here we present a technique, termed hierarchical topographic factor analysis (HTFA), for efficiently discovering full-brain networks in large multi-subject neuroimaging datasets. HTFA approximates each subject’s network by first re-representing each brain image in terms of the activations of a set of localized nodes, and then computing the covariance of the activation time series of these nodes. The number of nodes, along with their locations, sizes, and activations (over time) are learned from the data. Because the number of nodes is typically substantially smaller than the number of fMRI voxels, HTFA can be orders of magnitude more efficient than traditional voxel-based functional connectivity approaches. In one case study, we show that HTFA recovers the known connectivity patterns underlying a synthetic dataset. In a second case study, we illustrate how HTFA may be used to discover dynamic full-brain activity and connectivity patterns in real fMRI data, collected as participants listened to a story. In a third case study, we carried out a similar series of analyses on fMRI data collected as participants viewed an episode of a television show. In these latter case studies, we found that both the HTFA-derived activity and connectivity patterns may be used to reliably decode which moments in the story or show the participants were experiencing. Further, we found that these two classes of patterns contained partially non-overlapping information, such that classifiers trained on combinations of activity-based and dynamic connectivity-based features performed better than classifiers trained on activity or connectivity patterns alone. ER -