RT Journal Article
SR Electronic
T1 The infant airway microbiome in health and disease impacts later asthma development
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 012070
DO 10.1101/012070
A1 Shu Mei Teo
A1 Danny Mok
A1 Kym Pham
A1 Merci Kusel
A1 Michael Serralha
A1 Niamh Troy
A1 Barbara J. Holt
A1 Belinda J. Hales
A1 Michael L. Walker
A1 Elysia Hollams
A1 Yury H Bochkov
A1 Kristine Grindle
A1 Sebastian L. Johnston
A1 James E Gern
A1 Peter D. Sly
A1 Patrick G. Holt
A1 Kathryn E. Holt
A1 Michael Inouye
YR 2014
UL http://biorxiv.org/content/early/2014/12/02/012070.abstract
AB The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory illnesses (ARI). The development of asthma is initiated during infancy, driven by airway inflammation associated with infections. Here, we report viral and bacterial community profiling of NP aspirates across a birth cohort, capturing all lower respiratory illnesses during their first year. Most infants were initially colonized with Staphylococcus or Corynebacterium before stable colonization with Alloiococcus or Moraxella, with transient incursions of Streptococcus, Moraxella or Haemophilus marking virus-associated ARIs. Our data identify the NP microbiome as a determinant for infection spread to the lower airways, severity of accompanying inflammatory symptoms, and risk for future asthma development. Early asymptomatic colonization with Streptococcus was a strong asthma predictor, and antibiotic usage disrupted asymptomatic colonization patterns.