RT Journal Article
SR Electronic
T1 Cinnamon hydro alcoholic extract increased expression level of UCP3 gene in skeletal muscle of obese male Wistar Rats
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 105155
DO 10.1101/105155
A1 Elham Golmohamadi
A1 Sanaz Mahmazi
A1 Medi Rahnema
YR 2017
UL http://biorxiv.org/content/early/2017/02/02/105155.abstract
AB UCPs are the mitochondrial inner membrane proteins regulating basal metabolism. Ucp3 in muscle and adipose tissue helping metabolism and fat oxidation affecting thermogenesis, involve in fatty acid metabolism and energy homeostasis.42 adult rats divided into 6 groups including control group, the high-fat diet Obese group, experimental groups that in addition to the high-fat diet received 50,100,200 mgKg-1 doses of cinnamon extract and the sham group with 200 mgKg-1 extract treatment. RNA extracted from muscles, cDNA synthesized and Ucp3 gene expression level was examined by real-time PCR.In Obese rats’ muscle, significant decrease in UCP3 gene expression was observed but in exprimental groups there was significant increased level of UCP3 gene expression in 100, 50 mgKg-1 dose of treatment.UCP3 might be a target for pharmacological up regulation in treatment of obesity. Cinnamon might influence UCP3 expression, in a dose dependent manner and low dose was more effective.