RT Journal Article
SR Electronic
T1 SkinnerTrax: high-throughput behavior-dependent optogenetic stimulation of <em>Drosophila</em>
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 080614
DO 10.1101/080614
A1 Ulrich Stern
A1 Chung-Hui Yang
YR 2017
UL http://biorxiv.org/content/early/2017/02/01/080614.abstract
AB While red-shifted channelrhodopsin has been shown to be highly effective in activating CNS neurons in freely moving Drosophila, there were no existing high-throughput tools for closed-loop, behavior-dependent optogenetic stimulation of Drosophila. Here, we present SkinnerTrax to fill this void. SkinnerTrax stimulates individual flies promptly in response to their being at specific positions or performing specific actions. Importantly, SkinnerTrax was designed for and achieves significant throughput with simple and inexpensive components.