PT - JOURNAL ARTICLE AU - Ulrich Stern AU - Chung-Hui Yang TI - SkinnerTrax: high-throughput behavior-dependent optogenetic stimulation of <em>Drosophila</em> AID - 10.1101/080614 DP - 2017 Jan 01 TA - bioRxiv PG - 080614 4099 - http://biorxiv.org/content/early/2017/02/01/080614.short 4100 - http://biorxiv.org/content/early/2017/02/01/080614.full AB - While red-shifted channelrhodopsin has been shown to be highly effective in activating CNS neurons in freely moving Drosophila, there were no existing high-throughput tools for closed-loop, behavior-dependent optogenetic stimulation of Drosophila. Here, we present SkinnerTrax to fill this void. SkinnerTrax stimulates individual flies promptly in response to their being at specific positions or performing specific actions. Importantly, SkinnerTrax was designed for and achieves significant throughput with simple and inexpensive components.