TY - JOUR T1 - Progress Towards a Public Chemogenomic Set for Protein Kinases and a Call for Contributions JF - bioRxiv DO - 10.1101/104711 SP - 104711 AU - David H. Drewry AU - Carrow I. Wells AU - David M. Andrews AU - Richard Angell AU - Hassan Al-Ali AU - Alison D. Axtman AU - Stephen J. Capuzzi AU - Jonathan M. Elkins AU - Peter Ettmayer AU - Mathias Frederiksen AU - Opher Gileadi AU - Nathanael Gray AU - Alice Hooper AU - Stefan Knapp AU - Stefan Laufer AU - Ulrich Luecking AU - Susanne Müller AU - Eugene Muratov AU - R. Aldrin Denny AU - Kumar S. Saikatendu AU - Daniel K. Treiber AU - William J. Zuercher AU - Timothy M. Willson Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/01/31/104711.abstract N2 - Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases. ER -