TY - JOUR T1 - Wide-Scale Comparative Analysis of Longevity Genes and Genetic Interventions JF - bioRxiv DO - 10.1101/104182 SP - 104182 AU - Hagai Yanai AU - Arie Budovsky AU - Thomer Barzilay AU - Robi Tacutu AU - Vadim E. Fraifeld Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/01/30/104182.abstract N2 - Hundreds of genes have been identified as being involved in the control of lifespan in the four common model organisms (yeast, worm, fruit fly and mouse). A major challenge is to determine if longevity-associated genes (LAGs) are model-specific or may play a universal role as longevity regulators across diverse taxa. A wide-scale comparative analysis of the 1,805 known LAGs across 205 species revealed that (i) LAG orthologs are substantially over-represented, from bacteria to mammals, especially noted for essential LAGs; (ii) the effects on lifespan, when manipulating orthologous LAGs in different model organisms, were mostly concordant, despite of a high evolutionary distance between them; (iii) the most conserved LAGs were enriched in translational processes, energy metabolism, development, and DNA repair. The least conserved LAGs were enriched in autophagy (Fungi), G-proteins (Nematodes), and neuroactive ligand-receptor interactions (Chordata). The results also suggest that antagonistic pleiotropy is a conserved principle of aging. ER -