TY - JOUR T1 - The differential spatiotemporal expression pattern of shelterin genes throughout lifespan JF - bioRxiv DO - 10.1101/104299 SP - 104299 AU - Kay-Dietrich Wagner AU - Yilin Ying AU - Waiian Leong AU - Jie Jiang AU - Xuefei Hu AU - Yi Chen AU - Jean-François Michiels AU - Yiming Lu AU - Eric Gilson AU - Nicole Wagner AU - Jing Ye Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/01/30/104299.abstract N2 - Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in maintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends, some evidence suggests that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development throughout the lifespan. ER -