RT Journal Article SR Electronic T1 Fiber tractography using machine learning JF bioRxiv FD Cold Spring Harbor Laboratory SP 104190 DO 10.1101/104190 A1 Peter F. Neher A1 Marc-Alexandre Côté A1 Jean-Christophe Houde A1 Maxime Descoteaux A1 Klaus H. Maier-Hein YR 2017 UL http://biorxiv.org/content/early/2017/01/30/104190.abstract AB We present a fiber tractography approach based on a random forest classification and voting process, guiding each step of the streamline progression by directly processing raw diffusion-weighted signal intensities. For comparison to the state-of-the-art, i.e. tractography pipelines that rely on mathematical modeling, we performed a quantitative and qualitative evaluation with multiple phantom and in vivo experiments, including a comparison to the 96 submissions of the ISMRM tractography challenge 2015. The results demonstrate the vast potential of machine learning for fiber tractography.