%0 Journal Article %A Mohieddin Jafari %A Mehdi Mirzaie %T The evolution of central dogma of molecular biology: a logic-based dynamic approach %D 2017 %R 10.1101/103127 %J bioRxiv %P 103127 %X The age of the central dogma of molecular biology exceeded a half of a century. This biological axiom is grown up and now is more complicated. In this review, we renewed and re-expressed the central dogma as a mathematical model. It showed that the enhancement of the complexity kept pace with the gaining robustness.KeynotesThe central dogma of information flow is one of two main axiom in molecular biology.Boolean Modeling is useful to shed light on the conceptual notions in Biology.Although the molecular biology gets more complicated but it maintains its logical robustness.Biological notesMohieddin Jafari is an assistant professor in the Biotechnology Research Center of Pasteur Institute of Iran. The subject of his research includes systems and network biology, biological data mining and proteomics.Mehdi Mirzaie, is an assistant professor in the Department of Applied Mathematics at Tarbiat Modares University. His research field ranges broadly from structural bioinformatics and biostatistics to network science.Pasteur Institute of Iran (IPI) was founded in the heart of Iran’s capital, Tehran in the 1920s to pave the way for advanced research and to provide innovative programs in basic and applied medical sciences. Since 1983, Pasteur Institute of Iran offers a broad range of teaching activities in M.Sc. and Ph.D in different areas of medical and pharmaceutical biotechnology. It meets the specialized and scientific health demands of the local community.Tarbiat Modares University (TMU) was founded in 1982 in Tehran, Iran. The main mission of this university is to train academic staff as well as researchers for universities and higher education centers in Iran. %U https://www.biorxiv.org/content/biorxiv/early/2017/01/26/103127.full.pdf