RT Journal Article
SR Electronic
T1 Diverse yet highly selective interorgan crosstalk mechanisms shape the bodywide transcriptome landscape
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 102723
DO 10.1101/102723
A1 Norio Takada
A1 Madoka Omae
A1 Fumihiko Sagawa
A1 Neil C. Chi
A1 Satsuki Endo
A1 Satoshi Kozawa
A1 Thomas N. Sato
YR 2017
UL http://biorxiv.org/content/early/2017/01/24/102723.abstract
AB The network of functionally diverse organs is vital for organismal development and function. Despite such importance, the knowledge of the bodywide interorgan communication network is severely limited. Hence, we generate comprehensive bodywide transcriptome datasets following the systematic organ-ablations and organ-specific gene mutations in zebrafish and the data are integrated into a mechanistic interorgan network model. The experimental validation of the model unveils unexpectedly more diverse and selective interorgan crosstalk mechanisms than conventionally assumed to orchestrate the expression of 73 genes implicated for differential organ development and function across 8 organs. The findings provide an important insight into how differential organ development and function may be regulated at the organismal level by the cardiovascular system, which is a primary mediator of the interogan crosstalk in all vertebrates. Furthermore, the panoramic bodywide landscape shown herein and available at i-organs.atr.jp serves as a platform resource for studying organ-to-organ interactions at the organismal level.