TY - JOUR T1 - Diverse yet highly selective interorgan crosstalk mechanisms shape the bodywide transcriptome landscape JF - bioRxiv DO - 10.1101/102723 SP - 102723 AU - Norio Takada AU - Madoka Omae AU - Fumihiko Sagawa AU - Neil C. Chi AU - Satsuki Endo AU - Satoshi Kozawa AU - Thomas N. Sato Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/01/24/102723.abstract N2 - The network of functionally diverse organs is vital for organismal development and function. Despite such importance, the knowledge of the bodywide interorgan communication network is severely limited. Hence, we generate comprehensive bodywide transcriptome datasets following the systematic organ-ablations and organ-specific gene mutations in zebrafish and the data are integrated into a mechanistic interorgan network model. The experimental validation of the model unveils unexpectedly more diverse and selective interorgan crosstalk mechanisms than conventionally assumed to orchestrate the expression of 73 genes implicated for differential organ development and function across 8 organs. The findings provide an important insight into how differential organ development and function may be regulated at the organismal level by the cardiovascular system, which is a primary mediator of the interogan crosstalk in all vertebrates. Furthermore, the panoramic bodywide landscape shown herein and available at i-organs.atr.jp serves as a platform resource for studying organ-to-organ interactions at the organismal level. ER -