TY - JOUR T1 - Comprehensive comparison of large-scale tissue expression datasets JF - bioRxiv DO - 10.1101/010975 SP - 010975 AU - Alberto Santos AU - Kalliopi Tsafou AU - Christian Stolte AU - Sune Pletscher-Frankild AU - Seán I. O’Donoghue AU - Lars Juhl Jensen Y1 - 2014/01/01 UR - http://biorxiv.org/content/early/2014/11/10/010975.abstract N2 - For tissues to carry out their functions, they rely on the right proteins to be present. Several high-throughput technologies have been used to map out which proteins are expressed in which tissues; however, the data have not previously been systematically compared and integrated. We present a comprehensive evaluation of tissue expression data from a variety of experimental techniques and show that these agree surprisingly well with each other and with results from literature curation and text mining. We further found that most datasets support the assumed but not demonstrated distinction between tissue-specific and ubiquitous expression. By developing comparable confidence scores for all types of evidence, we show that it is possible to improve both quality and coverage by combining the datasets. To facilitate use and visualization of our work, we have developed the TISSUES resource (http://tissues.jensenlab.org), which makes all the scored and integrated data available through a single user-friendly web interface. ER -