RT Journal Article
SR Electronic
T1 Senescence associated protein degradation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 100388
DO 10.1101/100388
A1 Gerardo Ferbeyre
YR 2017
UL http://biorxiv.org/content/early/2017/01/15/100388.abstract
AB Senescent cells accumulate with age and contribute to pathologies associated to old age. The senescent program can be induced by pro-cancer stimuli or is developmentally controlled. In cells forced to senesce by expression of oncogenes or short telomeres, aberrant activation of the ERK/MAP kinase signaling pathway leads to selective protein degradation by the ubiquitin proteasome system. The proteins affected by this process control key cellular processes known to be defective in senescent cells. We discuss the evidence supporting a general role for senescence associated protein degradation for organismal aging.