TY - JOUR T1 - WASP: allele-specific software for robust discovery of molecular quantitative trait loci JF - bioRxiv DO - 10.1101/011221 SP - 011221 AU - Bryce van de Geijn AU - Graham McVicker AU - Yoav Gilad AU - Jonathan K. Pritchard Y1 - 2014/01/01 UR - http://biorxiv.org/content/early/2014/11/07/011221.abstract N2 - Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), however they are challenging to analyze and prone to technical artefacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and ChIP-seq reads, we demonstrate that our approach has a low error rate and is far more powerful than existing QTL mapping approaches. ER -