RT Journal Article
SR Electronic
T1 WASP: allele-specific software for robust discovery of molecular quantitative trait loci
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 011221
DO 10.1101/011221
A1 Bryce van de Geijn
A1 Graham McVicker
A1 Yoav Gilad
A1 Jonathan K. Pritchard
YR 2014
UL http://biorxiv.org/content/early/2014/11/07/011221.abstract
AB Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), however they are challenging to analyze and prone to technical artefacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and ChIP-seq reads, we demonstrate that our approach has a low error rate and is far more powerful than existing QTL mapping approaches.