PT  - JOURNAL ARTICLE
AU  - Bryce van de Geijn
AU  - Graham McVicker
AU  - Yoav Gilad
AU  - Jonathan K. Pritchard
TI  - WASP: allele-specific software for robust discovery of molecular quantitative trait loci
AID  - 10.1101/011221
DP  - 2014 Jan 01
TA  - bioRxiv
PG  - 011221
4099  - http://biorxiv.org/content/early/2014/11/07/011221.short
4100  - http://biorxiv.org/content/early/2014/11/07/011221.full
AB  - Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), however they are challenging to analyze and prone to technical artefacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and ChIP-seq reads, we demonstrate that our approach has a low error rate and is far more powerful than existing QTL mapping approaches.