RT Journal Article
SR Electronic
T1 Lateral geniculate neurons show robust ocular dominance plasticity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 097923
DO 10.1101/097923
A1 Juliane Jäpel
A1 Mark Hübener
A1 Tobias Bonhoeffer
A1 Tobias Rose
YR 2017
UL http://biorxiv.org/content/early/2017/01/03/097923.abstract
AB Experience-dependent plasticity in the mature visual system is considered exclusively cortical. Using chronic two-photon Ca2+ imaging, we found evidence against this tenet: dLGN cells showed robust ocular dominance shifts after monocular deprivation. Most, but not all responses of dLGN cell boutons in binocular visual cortex were monocular during baseline. Following deprivation, however, deprived-eye dominated boutons became responsive to the non-deprived eye. Thus, plasticity of dLGN neurons contributes to cortical ocular dominance shifts.