TY - JOUR T1 - SomaticSignatures: Inferring Mutational Signatures from Single Nucleotide Variants JF - bioRxiv DO - 10.1101/010686 SP - 010686 AU - Julian S. Gehring AU - Bernd Fischer AU - Michael Lawrence AU - Wolfgang Huber Y1 - 2014/01/01 UR - http://biorxiv.org/content/early/2014/10/24/010686.abstract N2 - Mutational signatures are patterns in the occurrence of somatic single nucleotide variants (SNVs) that can reflect underlying mutational processes. The SomaticSignatures package provides flexible, interoperable, and easy-to-use tools that identify such signatures in cancer sequencing studies. It facilitates large-scale, cross-dataset estimation of mutational signatures, implements existing methods for pattern decomposition, supports extension through user-defined methods and integrates with Bioconductor workflows.The R package SomaticSignatures is available as part of the Bioconductor project (R Core Team, 2014; Gentleman et al., 2004). Its documentation provides additional details on the methodology and demonstrates applications to biological datasets. ER -