RT Journal Article
SR Electronic
T1 Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 095364
DO 10.1101/095364
A1 Xing Ji
A1 Fang Chen
A1 Yafeng Zhou
A1 Jia Li
A1 Yuying Yuan
A1 Yu Mo
A1 Qiang Liu
A1 Jen-Yu Tseng
A1 Diego Shih-Chieh Lin
A1 Shu-Huei Shen
A1 Yu Liu
A1 Weiping Ye
A1 Hongyun Zhang
A1 Na Liu
A1 Li Shen
A1 Xin Jin
A1 Pi-Lin Sung
A1 Mao Mao
YR 2016
UL http://biorxiv.org/content/early/2016/12/19/095364.abstract
AB Noninvasive prenatal test (NIPT) has been widely used as a screening test for trisomy 13, 18 and 21 worldwide. Recently, coexistence of maternal malignancy and pregnancy has drawn increasing attention in NIPT studies. Malignancy in pregnant women potentially affected NIPT results, which may cause false positive results or failed tests. However, no such case has ever been reported in Asian population. In this study, for the first time, we reported a stage III dysgerminoma and advanced gastric cancer during pregnancy accidentally identified during NIPT tests. These two women showed aberrant chromosome aneuploidies in NIPT results and concordant pattern of genome disruption found in tumor samples. The findings in this study further validate the effect of maternal malignancy on NIPT results and strengthen the possibility of detecting malignant tumors through NIPT in the future.