PT  - JOURNAL ARTICLE
AU  - Xing Ji
AU  - Fang Chen
AU  - Yafeng Zhou
AU  - Jia Li
AU  - Yuying Yuan
AU  - Yu Mo
AU  - Qiang Liu
AU  - Jen-Yu Tseng
AU  - Diego Shih-Chieh Lin
AU  - Shu-Huei Shen
AU  - Yu Liu
AU  - Weiping Ye
AU  - Hongyun Zhang
AU  - Na Liu
AU  - Li Shen
AU  - Xin Jin
AU  - Pi-Lin Sung
AU  - Mao Mao
TI  - Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test
AID  - 10.1101/095364
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 095364
4099  - http://biorxiv.org/content/early/2016/12/19/095364.short
4100  - http://biorxiv.org/content/early/2016/12/19/095364.full
AB  - Noninvasive prenatal test (NIPT) has been widely used as a screening test for trisomy 13, 18 and 21 worldwide. Recently, coexistence of maternal malignancy and pregnancy has drawn increasing attention in NIPT studies. Malignancy in pregnant women potentially affected NIPT results, which may cause false positive results or failed tests. However, no such case has ever been reported in Asian population. In this study, for the first time, we reported a stage III dysgerminoma and advanced gastric cancer during pregnancy accidentally identified during NIPT tests. These two women showed aberrant chromosome aneuploidies in NIPT results and concordant pattern of genome disruption found in tumor samples. The findings in this study further validate the effect of maternal malignancy on NIPT results and strengthen the possibility of detecting malignant tumors through NIPT in the future.