RT Journal Article
SR Electronic
T1 Architecture and dynamics of the jasmonic acid gene regulatory network
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 093682
DO 10.1101/093682
A1 Richard J. Hickman
A1 Marcel C. Van Verk
A1 Anja J.H. Van Dijken
A1 Marciel Pereira Mendes
A1 Irene A. Vos
A1 Lotte Caarls
A1 Merel Steenbergen
A1 Ivo Van Der Nagel
A1 Gert Jan Wesselink
A1 Aleksey Jironkin
A1 Adam Talbot
A1 Johanna Rhodes
A1 Michel de Vries
A1 Robert C. Schuurink
A1 Katherine Denby
A1 Corné M.J. Pieterse
A1 Saskia C.M. Van Wees
YR 2016
UL http://biorxiv.org/content/early/2016/12/13/093682.abstract
AB The phytohormone jasmonic acid (JA) is a critical regulator of plant growth and defense. To significantly advance our understanding of the architecture and dynamics of the JA gene regulatory network, we performed high-resolution RNA-Seq time series analyses of methyl JA-treated Arabidopsis thaliana. Computational analysis unraveled in detail the chronology of events that occur during the early and later phases of the JA response. Several transcription factors, including ERF16 and bHLH27, were uncovered as early components of the JA gene regulatory network with a role in pathogen and insect resistance. Moreover, analysis of subnetworks surrounding the JA-induced transcription factors ORA47, RAP2.6L, and ANAC055 provided novel insights into their regulatory role of defined JA network modules. Collectively, our work illuminates the complexity of the JA gene regulatory network, pinpoints to novel regulators, and provides a valuable resource for future studies on the function of JA signaling components in plant defense and development.