RT Journal Article SR Electronic T1 A space-jump derivation for non-local models of cell-cell adhesion and non-local chemotaxis JF bioRxiv FD Cold Spring Harbor Laboratory SP 093617 DO 10.1101/093617 A1 Andreas Buttenschön A1 Thomas Hillen A1 Alf Gerisch A1 Kevin J. Painter YR 2016 UL http://biorxiv.org/content/early/2016/12/13/093617.abstract AB Cellular adhesion provides one of the fundamental forms of biological interaction between cells and their surroundings, yet the continuum modelling of cellular adhesion has remained mathematically challenging. In 2006, Armstrong et. al. proposed a mathematical model in the form of an integro-partial differential equation. Although successful in applications, a derivation from an underlying stochastic random walk has remained elusive. In this work we develop a framework by which non-local models can be derived from a space-jump process. We show how the notions of motility and a cell polarization vector can be naturally included. With this derivation we are able to include microscopic biological properties into the model. We show that particular choices yield the original Armstrong model, while others lead to more general models, including a doubly non-local adhesion model and non-local chemotaxis models. Finally, we use random walk simulations to confirm that the corresponding continuum model represents the mean field behaviour of the stochastic random walk.Mathematics Subject Classification (2000) 92C17PACS 92C17