PT  - JOURNAL ARTICLE
AU  - Aurélien Naldi
AU  - Pedro T. Monteiro
AU  - Christoph Müssel
AU  - the Consortium for Logical Models and Tools
AU  - Hans A. Kestler
AU  - Denis Thieffry
AU  - Ioannis Xenarios
AU  - Julio Saez-Rodriguez
AU  - Tomas Helikar
AU  - Claudine Chaouiya
TI  - Cooperative development of logical modelling standards and tools with CoLoMoTo
AID  - 10.1101/010504
DP  - 2014 Jan 01
TA  - bioRxiv
PG  - 010504
4099  - http://biorxiv.org/content/early/2014/10/19/010504.short
4100  - http://biorxiv.org/content/early/2014/10/19/010504.full
AB  - The identification of large regulatory and signalling networks involved in the control of crucial cellular processes calls for proper modelling approaches. Indeed, models can help elucidate properties of these networks, understand their behaviour, and provide (testable) predictions by performing in silico experiments. In this context, qualitative, logical frameworks have emerged as relevant approaches as demonstrated by a growing number of published models, along with new methodologies and software tools. This productive activity now requires a concerted effort to ensure model reusability and interoperability between tools. Here, we outline the logical modelling framework and present the most important achievements of the Consortium for Logical Models and Tools, along with future objectives. This open community welcomes contributions from all researchers interested in logical modelling or in related mathematical and computational developments.