RT Journal Article
SR Electronic
T1 Non Diaphanous Formin Delphilin Acts as a Barbed End Capping Protein
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 093104
DO 10.1101/093104
A1 Priyanka Dutta
A1 Sankar Maiti
YR 2016
UL http://biorxiv.org/content/early/2016/12/11/093104.abstract
AB Formins are important for actin polymerization. Delphilin is a unique formin having PDZ domains and FH1, FH2 domains at its N and C terminus respectively. In this study we observed that Delphilin binds to actin filaments, and have negligible actin filament polymerizing activity. Delphilin inhibits actin filament elongation like barbed end capping protein CapZ. In vitro, Delphilin stabilized actin filaments by inhibiting actin filament depolymerisation. Therefore, our study demonstrates Delphilin as an actin-filament capping protein.