RT Journal Article
SR Electronic
T1 Relationships between chromosomal aberration breakpoints and chromosomal contacts: biophysical modeling study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 089508
DO 10.1101/089508
A1 S. V. Slanina
A1 Y. A. Eidelman
A1 A. V. Aleshchenko
A1 S. G. Andreev
YR 2016
UL http://biorxiv.org/content/early/2016/11/25/089508.abstract
AB Radiation-induced chromosomal exchange aberrations (CAs) are formed presumably at contacts of damaged chromosomal loci. For sparsely ionizing radiation, distribution of aberrations along the chromosome should depend on distribution of contacts, i.e. on 3D organization of the chromosome. The progress in experimental techniques for study of chromosomal contacts and for precise localization of aberration breakpoints allows to verify contacts-based mechanisms of CA formation experimentally. In the present work, the polymer model of mouse interphase chromosome 18 is developed. On this basis the experimental data on contacts and aberrations are jointly analyzed. We demonstrate high correlation between chromosomal contacts and aberrations breakpoint distributions. Possible factors and alternative mechanisms which could modify breakpoint distributions are discussed.