RT Journal Article SR Electronic T1 Age and sex affect intersubject correlation of EEG throughout development JF bioRxiv FD Cold Spring Harbor Laboratory SP 089060 DO 10.1101/089060 A1 Agustin Petroni A1 Samantha Cohen A1 Nicolas Langer A1 Simon Henin A1 Tamara Vanderwal A1 Michael P. Milham A1 Lucas C. Parra YR 2016 UL http://biorxiv.org/content/early/2016/11/22/089060.abstract AB Recent efforts have aimed to characterize clinical pediatric populations by using neurophysiological tests in addition to behavioral assays. Here we report on a data collection effort in which electroencephalography (EEG) was recorded in both juveniles and adults (N=114 participants, ages 6-44 years of age) during various stimulation protocols. The present analysis focuses on how neural responses during passive viewing of naturalistic videos vary with age and sex, and in particular, how similar they are within developmental groups. Similarity of neural responses was measured as the inter-subject correlation of the EEG. Stimulus-evoked neural responses are more similar among children and decrease in similarity with age. Among children, males respond more similarly to each other than females. This was uniformly true for a variety of videos. The decrease in group similarity with age may result from an overall decline in the magnitude of evoked responses, but this cannot explain the sex differences found in the young. We therefore propose that as children mature, neural function may become more variable.