RT Journal Article
SR Electronic
T1 Human Cytomegalovirus Intrahost Evolution–A New Avenue for Understanding and Controlling Herpesvirus Infections
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 009571
DO 10.1101/009571
A1 Nicholas Renzette
A1 Laura Gibson
A1 Jeffrey D. Jensen
A1 Timothy F. Kowalik
YR 2014
UL http://biorxiv.org/content/early/2014/09/30/009571.abstract
AB Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.