TY - JOUR T1 - Automatic Tracing of Ultra-Volume of Neuronal Images JF - bioRxiv DO - 10.1101/087726 SP - 087726 AU - Hanchuan Peng AU - Zhi Zhou AU - Erik Meijering AU - Ting Zhao AU - Giorgio A. Ascoli AU - Michael Hawrylycz Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/11/14/087726.abstract N2 - Despite substantial advancement in the automatic tracing of neurons' morphology in recent years, it is challenging to apply the existing algorithms to very large image datasets containing billions or more voxels. We introduce UltraTracer, a solution designed to extend any base neuron-tracing algorithm to be able to trace virtually unlimited data volumes. We applied this approach to neuron-tracing algorithms with completely different design principles and tested on challenging human and mouse neuron datasets that have hundreds of billions of voxels. Results indicate that UltraTracer is scalable, accurate, and about 3 to 6 times more efficient compared to other state-of-the-art approaches. ER -