TY - JOUR T1 - Interneuronal mechanisms of hippocampal theta oscillation in full-scale model of the CA1 circuit JF - bioRxiv DO - 10.1101/087403 SP - 087403 AU - Marianne J. Bezaire AU - Ivan Raikov AU - Kelly Burk AU - Dhrumil Vyas AU - Ivan Soltesz Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/11/12/087403.abstract N2 - The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct in terneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation. These simulations reveal new insights into the spatiotemporal organization of the CA1 circuit during theta oscillations. ER -