PT - JOURNAL ARTICLE AU - Yuan Zhou AU - Jie Chen AU - Yu L.L. Luo AU - Dang Zheng AU - Li-Lin Rao AU - Xinying Li AU - Jianxin Zhang AU - Shu Li AU - Karl Friston AU - Xi-Nian Zuo TI - Genetic overlap between in-scanner head motion and the default network connectivity AID - 10.1101/087023 DP - 2016 Jan 01 TA - bioRxiv PG - 087023 4099 - http://biorxiv.org/content/early/2016/11/11/087023.short 4100 - http://biorxiv.org/content/early/2016/11/11/087023.full AB - The association between in-scanner head motion and intrinsic functional connectivity (iFC) may confound explanations for individual differences in functional connectomics. However, the etiology of the correlation between head motion and iFC has not been established. This study aimed to investigate genetic and environmental contributions on the association between head motion and iFC using a twin dataset (175 same-sex twin pairs, aged 14-23 years, 48% females). After establishing that both head motion and default network iFC are moderately heritable, we found large genetic correlations (-0.52 to -0.73) between head motion and the default network iFCs. Common genes can explain 48% - 61% of the negative phenotypic correlation between the two phenotypes. These results advance our understanding of the relationship between head motion and iFC, and may have profound implications for interpreting individual differences in default network connectivity in clinical research and brain-behavior association.