RT Journal Article
SR Electronic
T1 Tractography-based connectomes are dominated by false-positive connections
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 084137
DO 10.1101/084137
A1 Klaus H. Maier-Hein
A1 Peter Neher
A1 Jean-Christophe Houde
A1 Marc-Alexandre Côté
A1 Eleftherios Garyfallidis
A1 Jidan Zhong
A1 Maxime Chamberland
A1 Fang-Cheng Yeh
A1 Ying-Chia Lin
A1 Qing Ji
A1 Wilburn E. Reddick
A1 John O. Glass
A1 David Qixiang Chen
A1 Yuanjing Feng
A1 Chengfeng Gao
A1 Ye Wu
A1 Jieyan Ma
A1 H Renjie
A1 Qiang Li
A1 Carl-Fredrik Westin
A1 Samuel Deslauriers-Gauthier
A1 J. Omar Ocegueda González
A1 Michael Paquette
A1 Samuel St-Jean
A1 Gabriel Girard
A1 François Rheault
A1 Jasmeen Sidhu
A1 Chantal M.W. Tax
A1 Fenghua Guo
A1 Hamed Y. Mesri
A1 Szabolcs Dávid
A1 Martijn Froeling
A1 Anneriet M. Heemskerk
A1 Alexander Leemans
A1 Arnaud Boré
A1 Basile Pinsard
A1 Christophe Bedetti
A1 Matthieu Desrosiers
A1 Simona Brambati
A1 Julien Doyon
A1 Alessia Sarica
A1 Roberta Vasta
A1 Antonio Cerasa
A1 Aldo Quattrone
A1 Jason Yeatman
A1 Ali R. Khan
A1 Wes Hodges
A1 Simon Alexander
A1 David Romascano
A1 Muhamed Barakovic
A1 Anna Auría
A1 Oscar Esteban
A1 Alia Lemkaddem
A1 Jean-Philippe Thiran
A1 H. Ertan Cetingul
A1 Benjamin L. Odry
A1 Boris Mailhe
A1 Mariappan S. Nadar
A1 Fabrizio Pizzagalli
A1 Gautam Prasad
A1 Julio E. Villalon-Reina
A1 Justin Galvis
A1 Paul M. Thompson
A1 Francisco De Santiago Requejo
A1 Pedro Luque Laguna
A1 Luis Miguel Lacerda
A1 Rachel Barrett
A1 Flavio Dell’Acqua
A1 Marco Catani
A1 Laurent Petit
A1 Emmanuel Caruyer
A1 Alessandro Daducci
A1 Tim B. Dyrby
A1 Tim Holland-Letz
A1 Claus C. Hilgetag
A1 Bram Stieltjes
A1 Maxime Descoteaux
YR 2016
UL http://biorxiv.org/content/early/2016/11/07/084137.abstract
AB Fiber tractography based on non-invasive diffusion imaging is at the heart of connectivity studies of the human brain. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain dataset with ground truth white matter tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. While most state-of-the-art algorithms reconstructed 90% of ground truth bundles to at least some extent, on average they produced four times more invalid than valid bundles. About half of the invalid bundles occurred systematically in the majority of submissions. Our results demonstrate fundamental ambiguities inherent to tract reconstruction methods based on diffusion orientation information, with critical consequences for the approach of diffusion tractography in particular and human connectivity studies in general.