RT Journal Article
SR Electronic
T1 TrkB signaling underlies the rapid antidepressant effects of isoflurane
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 084525
DO 10.1101/084525
A1 Hanna Antila
A1 Plinio Casarotto
A1 Dina Popova
A1 Pia Sipilä
A1 Ramon Guirado
A1 Samuel Kohtala
A1 Maria Ryazantseva
A1 Liisa Vesa
A1 Jesse Lindholm
A1 Ipek Yalcin
A1 Vinicius Sato
A1 Helka Gööse
A1 Sarah Lemprièref
A1 Joshua Cordeira
A1 Henri Autio
A1 Mikhail Kislin
A1 Maribel Rios
A1 Sâmia Joca
A1 Leonard Khiroug
A1 Sari Lauri
A1 Markku Varjosalo
A1 Seth G.N. Grant
A1 Tomi Taira
A1 Eero Castrén
A1 Tomi Rantamäki
YR 2016
UL http://biorxiv.org/content/early/2016/11/02/084525.abstract
AB Neuronal plasticity induced by signaling through BDNF receptor TrkB has been implicated in the actions of antidepressants, including the rapid-acting antidepressant ketamine. We show that isoflurane induced transphosphorylation of TrkB by Src family kinases, stimulates the mTor signaling pathway and promotes neuronal plasticity and antidepressant-like behavior in rodents. Our findings provide a neurobiological basis for the clinically observed antidepressant effects of isoflurane and encourage its further evaluation as a rapid-acting antidepressant treatment devoid of the psychotomimetic side effects of ketamine.