TY - JOUR T1 - TrkB signaling underlies the rapid antidepressant effects of isoflurane JF - bioRxiv DO - 10.1101/084525 SP - 084525 AU - Hanna Antila AU - Plinio Casarotto AU - Dina Popova AU - Pia Sipilä AU - Ramon Guirado AU - Samuel Kohtala AU - Maria Ryazantseva AU - Liisa Vesa AU - Jesse Lindholm AU - Ipek Yalcin AU - Vinicius Sato AU - Helka Gööse AU - Sarah Lemprièref AU - Joshua Cordeira AU - Henri Autio AU - Mikhail Kislin AU - Maribel Rios AU - Sâmia Joca AU - Leonard Khiroug AU - Sari Lauri AU - Markku Varjosalo AU - Seth G.N. Grant AU - Tomi Taira AU - Eero Castrén AU - Tomi Rantamäki Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/11/02/084525.abstract N2 - Neuronal plasticity induced by signaling through BDNF receptor TrkB has been implicated in the actions of antidepressants, including the rapid-acting antidepressant ketamine. We show that isoflurane induced transphosphorylation of TrkB by Src family kinases, stimulates the mTor signaling pathway and promotes neuronal plasticity and antidepressant-like behavior in rodents. Our findings provide a neurobiological basis for the clinically observed antidepressant effects of isoflurane and encourage its further evaluation as a rapid-acting antidepressant treatment devoid of the psychotomimetic side effects of ketamine. ER -