RT Journal Article
SR Electronic
T1 Functional consequences of pre- and postsynaptic expression of synaptic plasticity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 075317
DO 10.1101/075317
A1 Rui Ponte Costa
A1 Beatriz E.P. Mizusaki
A1 P. Jesper Sjöström
A1 Mark C. W. van Rossum
YR 2016
UL http://biorxiv.org/content/early/2016/10/29/075317.abstract
AB Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts 1) more reliable receptive fields and sensory perception, 2) rapid recovery of forgotten information (memory savings) and 3) reduced response latencies, compared to a model with postsynaptic expression only. Finally we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.