RT Journal Article
SR Electronic
T1 Neuronal synchrony and the relation between the BOLD response and the local field potential
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 083840
DO 10.1101/083840
A1 Dora Hermes
A1 Mai Nguyen
A1 Jonathan Winawer
YR 2016
UL http://biorxiv.org/content/early/2016/10/28/083840.abstract
AB The most widespread measures of human brain activity are the blood oxygen level dependent (BOLD) signal and surface field potential. These measures provide complementary information about human brain activity. To develop an understanding of how to interpret these signals, we developed a model of (a) neuronal population responses, and (b) transformations from neuronal responses into the fMRI BOLD signal and electrocorticographic (ECoG) field potential. Rather than seeking a transformation between signals directly, this approach interprets each measure with respect to the underlying neuronal population responses. Our model accounts for the relationship between BOLD and ECoG data from human visual cortex (V1-V3), matching in three ways: BOLD and ECoG broadband were positively correlated, BOLD and alpha (8-13Hz) were negatively correlated, and BOLD and narrowband gamma (30-80Hz) did not correlate. We infer that features of the field potential that are uncorrelated with BOLD arise largely from changes in synchrony, rather than level, of neuronal activity.