RT Journal Article SR Electronic T1 The transcriptional repressor HIC1 regulates intestinal immune homeostasis JF bioRxiv FD Cold Spring Harbor Laboratory SP 083873 DO 10.1101/083873 A1 Kyle Burrows A1 Frann Antignano A1 Michael Bramhall A1 Alistair Chenery A1 Sebastian Scheer A1 Vladimir Korinek A1 T. Michael Underhill A1 Colby Zaph YR 2016 UL http://biorxiv.org/content/early/2016/10/28/083873.abstract AB The intestine is a unique immune environment that must respond to infectious organisms but remain tolerant to commensal microbes and food antigens. However, the molecular mechanisms that regulate immune cell function in the intestine remain unclear. Here we identify the POK/ZBTB family transcription factor Hypermethylated in cancer 1 (HIC1, ZBTB29) as a central component of immunity and inflammation in the intestine. HIC1 is specifically expressed in immune cells in the intestinal lamina propria (LP) in the steady state and mice with a T cell-specific deletion of HIC1 have reduced numbers of T cells in the LP. HIC1 expression is regulated by the Vitamin A metabolite retinoic acid, as mice raised on a Vitamin A-deficient diet lack HIC1-positive cells in the intestine. HIC1-deficient T cells overproduce IL-17A in vitro and in vivo, and fail to induce intestinal inflammation, identifying a critical role for HIC1 in the regulation of T cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions.