RT Journal Article SR Electronic T1 Compromised External Validity: Federally Produced Cannabis Does Not Reflect Legal Markets JF bioRxiv FD Cold Spring Harbor Laboratory SP 083444 DO 10.1101/083444 A1 Daniela Vergara A1 L. Cinnamon Bidwell A1 Reggie Gaudino A1 Anthony Torres A1 Gary Du A1 Travis C. Ruthenburg A1 Kymron deCesare A1 Donald P. Land A1 Kent E. Hutchison A1 Nolan C. Kane YR 2016 UL http://biorxiv.org/content/early/2016/10/26/083444.abstract AB As the most widely used illicit drug, the basis of the fastest growing major industry in the US, and as a source of numerous under-studied psychoactive compounds, understanding the psychological and physiological effects of Cannabis is essential. The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of Cannabis for use in US research studies. We sought to compare the chemical profiles of Cannabis varieties that are available to consumers in states that have state-legalized use versus what is available to researchers interested in studying the plant and its effects. Our results demonstrate that the federally produced Cannabis has significantly less variety and lower concentrations of cannabinoids. Current research, which has focused on material that is far less diverse and less potent than that used by the public, limits our understanding of the plant’s chemical, biological, psychological, medical, and pharmacological properties. Investigation is urgently needed on the diverse forms of Cannabis used by the public in state-legal markets.