PT  - JOURNAL ARTICLE
AU  - Stephen Bridgett
AU  - James Campbell
AU  - Christopher J. Lord
AU  - Colm J. Ryan
TI  - CancerGD: a resource for identifying and interpreting genetic dependencies in cancer
AID  - 10.1101/081992
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 081992
4099  - http://biorxiv.org/content/early/2016/10/26/081992.short
4100  - http://biorxiv.org/content/early/2016/10/26/081992.full
AB  - Genes whose function is selectively essential in the presence of cancer associated genetic aberrations represent promising targets for the development of precision therapeutics. Here we present CancerGD (www.cancergd.org), a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks.