RT Journal Article
SR Electronic
T1 How to fold intricately: using theory and experiments to unravel the properties of knotted proteins
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 082446
DO 10.1101/082446
A1 Sophie E. Jackson
A1 Antonio Suma
A1 Cristian Micheletti
YR 2016
UL http://biorxiv.org/content/early/2016/10/21/082446.abstract
AB Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues that could be tackled with either or both approaches are finally pointed out.