PT  - JOURNAL ARTICLE
AU  - Sophie E. Jackson
AU  - Antonio Suma
AU  - Cristian Micheletti
TI  - How to fold intricately: using theory and experiments to unravel the properties of knotted proteins
AID  - 10.1101/082446
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 082446
4099  - http://biorxiv.org/content/early/2016/10/21/082446.short
4100  - http://biorxiv.org/content/early/2016/10/21/082446.full
AB  - Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues that could be tackled with either or both approaches are finally pointed out.