TY - JOUR T1 - Potent optogenetic inhibition of behavior with anion channelrhodopsins JF - bioRxiv DO - 10.1101/082255 SP - 082255 AU - Farhan Mohammad AU - James C. Stewart AU - Stanislav Ott AU - Katarina Chlebikova AU - Jia Yi Chua AU - Tong-Wey Koh AU - Joses Ho AU - Adam Claridge-Chang Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/10/20/082255.abstract N2 - Optogenetics employs light exposure to manipulate physiology in genetically modified organisms. There are abundant tools for optogenetic excitation of neuronal activity, but the limitations of current activity photo-inhibitors present an obstacle to demonstrating the necessity of specific neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit a range of systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, demonstrating their broad utility to the circuit analysis of behavior. ER -