TY - JOUR T1 - Reactive Oxygen Species Regulate Activity-Dependent Neuronal Structural Plasticity JF - bioRxiv DO - 10.1101/081968 SP - 081968 AU - Matthew C. W. Oswald AU - Paul S. Brooks AU - Maarten F. Zwart AU - Amrita Mukherjee AU - Ryan J. H. West AU - Khomgrit Morarach AU - Sean T. Sweeney AU - Matthias Landgraf Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/10/19/081968.abstract N2 - Neurons adjust their excitability, connectivity and structure in response to changes in activity, yet how neurons sense their activity level remains unclear. We have found that motorneurons cell-autonomously monitor their activity by responding to the levels of reactive oxygen species (ROS), a metabolic mitochondrial byproduct. The highly conserved Parkinson's disease-linked protein DJ1b is central to this, acting as a redox sensor to regulate pre- and postsynaptic structural plasticity via activation of the PI3Kinase pathway. ER -