RT Journal Article
SR Electronic
T1 Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.11.12.468385
DO 10.1101/2021.11.12.468385
A1 Bethany M. Coad
A1 Parisa A. Ghomroudi
A1 Rebecca Sims
A1 John P. Aggleton
A1 Seralynne D. Vann
A1 Claudia Metzler-Baddeley
YR 2021
UL http://biorxiv.org/content/early/2021/11/16/2021.11.12.468385.abstract
AB Characterizing age- and risk-related hippocampal vulnerabilities may inform about the neural underpinnings of cognitive decline. We studied the impact of three risk-factors, Apolipoprotein (APOE)-ε4, a family history of dementia, and central obesity, on CA1, CA2/3, dentate gyrus (DG) and subiculum in 158 cognitively healthy adults (38-71 years). Subfields were labelled with the Automatic Segmentation of Hippocampal Subfields (ASHS) and FreeSurfer (version 6) protocols. Volumetric and microstructural measurements from quantitative magnetization transfer and Neurite Orientation Density and Dispersion Imaging were extracted for each subfield and reduced to three principal components capturing apparent myelin/neurite packing, size/complexity, and metabolism. Aging was associated with an inverse U-shaped curve on myelin/neurite packing and affected all subfields. Obesity led to reductions in myelin/neurite packing and size/complexity regardless of APOE and FH status. However, amongst individuals with a healthy Waist-Hip-Ratio, APOE ε4 carriers showed lower size/complexity than non-carriers. Protocol type did not affect this risk pattern. These findings provide novel evidence for interactive effects between APOE and central obesity on the hippocampal formation of cognitively healthy adults.HighlightsAge-related inverted U-shaped curve of hippocampal myelin/neurite packingObesity-related reductions of hippocampal myelin/neurite packing and size/complexityAPOE modifies the effects of obesity on hippocampal size/complexityAge-related slowing of spatial navigationNo APOE, family history, or obesity effects on cognitionCompeting Interest StatementThe authors have declared no competing interest.